Research


main questions: -

  • How, when and where do B cells present antigen to T cells in vivo? Is their function quantitative (follow-0n APC after DC) or do B cells deliver unique signals?

  • How is the programming of T cell responses by B cells achieved? What is the interplay between BCR and TLR signals in the process?

  • B cells are needed for the optimal development of CD4 T cell memory; what is the basis of this?

  • Is movement through the follicular helper T cell (Tfh) compartment a necessary requisite for formation of CD4 memory?    

  • How are conflicting transcriptional programmes balanced and integrated  during T cell differentiation?   

  • What factors influence the decision to generate short-lived versus long-lived plasma cells? How does chronic antigen supply affect this?  

 

Collaborators:

Dr Mohini Gray (CIR, QMRI, University of Edinburgh)

Dr Pietro Mastroeni (Cambridge Veterinary School)